Urgent · Within 72 Hours

PEP: Emergency HIV Prevention After Exposure

Post-Exposure Prophylaxis (PEP) is a short course of medicine that can stop HIV taking hold after a possible exposure — but only if it’s started fast. Confidential, specialist-led care in Greater Noida.

MRCP (UK), MD, DNB2-year Fellowship in Infectious Diseases & HIV, Tata MemorialVisiting Consultant, Infectious Diseases, Fortis Greater Noida

What you need to know now

PEP must start within 72 hours — sooner is better
It’s a 28-day course of antiretroviral tablets
Substantially reduces HIV risk — not a 100% guarantee
Confidential, judgment-free care
If exposure was in the last 72 hours, call before reading further — time matters most. Clinic closed? See what to do at night.

⚠️ Possible exposure in the last 72 hours?

PEP works best when started as early as possible — ideally within hours, and no later than 72 hours. During clinic hours, call or WhatsApp now for an urgent, confidential consultation. At night, follow the steps just below.

🌙 Exposure at night, or the clinic is closed?

Send us a WhatsApp message now — it is seen first thing in the morning — and book an online consultation with Dr. Manuj Sondhi from 8 AM. An overnight wait usually still leaves you well within the 72-hour window, and if PEP is needed, it can be started the same day.

Do not wait for morning — go to the nearest hospital emergency department tonight if:

  • more than 48 hours have already passed since the exposure
  • it was a sexual assault (see what to do first)
  • it was a needle-stick or blood exposure from someone known to have HIV
  • you are injured, bleeding or feel unsafe — call 112

If you would simply rather not wait, any hospital emergency department can assess you and start PEP tonight. Starting sooner is always better.

🔒
Private and confidential. A respectful, judgment-free consultation with Dr. Manuj Sondhi. Your information is handled confidentially, in line with Indian law.
✓ Reviewed by Dr. Manuj Sondhi, MRCP (UK), MD, DNB — Consultant Physician & Diabetologist · Visiting Consultant, Infectious Diseases, Fortis Greater Noida
Last reviewed: September 2026 · Reg. No. 12-42985 · ORCID: 0009-0007-0394-9480
Do not start random HIV medicines on your own. PEP needs the right drug combination, correct timing, a baseline HIV test, kidney/liver safety checks, a hepatitis assessment and follow-up. The wrong medicine — or stopping early — can cause harm and confusion. Start PEP only under medical supervision.

PEP (Post-Exposure Prophylaxis) is emergency HIV prevention. If you may have been exposed to HIV — through sex, a condom that broke, a needle, or an assault — taking antiretroviral medicine soon afterwards can prevent the virus from establishing infection. The single most important factor is how quickly you start.

The Time Window

Why 72 hours is the deadline

HIV needs time to establish itself in the body after exposure. PEP works by blocking that process — but the window is narrow:

  • Start as soon as possible — ideally within a few hours of exposure.
  • Absolute limit is 72 hours (3 days). After 72 hours, PEP is generally not recommended because the expected benefit is very low — but you should still seek HIV testing, STI testing and prevention advice.
  • Earlier = better. Effectiveness is highest in the first 24 hours and declines as time passes.
If you are inside the 72-hour window, do not wait to finish researching. Call or WhatsApp the clinic now — the consultation can happen quickly and confidentially. If it is night-time, follow the after-hours steps.
When PEP Is Needed

Situations PEP is considered for

PEP is considered after a realistic possibility of HIV exposure, such as:

Condom failure or unprotected sex

With a partner who is HIV-positive or of unknown status.

Sexual assault

PEP is part of urgent care after an assault. See what to do first.

Needle or sharps injury

Including occupational (healthcare) and shared-needle exposures.

Other blood/fluid contact

Significant exposure to blood or body fluids of unknown status.

The doctor will assess the actual level of risk — not every contact needs PEP — and advise honestly either way.

After a Sexual Assault

If this was a sexual assault

What happened is not your fault. Whoever you are, you deserve urgent, respectful care — and HIV PEP works best when it is started within hours.

1

Get to a safe place

If you are in danger or badly hurt, call 112 now.

2

Go to the nearest hospital emergency department

Go as soon as you can, day or night. Under Indian law, every hospital — government or private — must give survivors of rape and child sexual abuse immediate medical treatment free of charge. You do not need to file a police complaint before you are treated.

3

Know what urgent care includes

Treatment of any injuries, HIV PEP (within 72 hours), emergency contraception if needed, prevention and testing for other infections, and emotional support.

4

The examination is your choice

The medical examination and collection of evidence are done only with your informed consent, and you can say no to any part of it. A government hospital can carry out the medico-legal examination. If you can, try not to bathe, wash or change clothes before it — but never delay care for this.

5

About the police

Hospitals and clinics are required by law to inform the police when they treat a survivor of sexual assault. You still decide whether to file a police complaint, and your medical care does not depend on it.

Support lines: Women Helpline 181 (24×7) can connect you with the district One Stop Centre (Sakhi) for medical, legal and counselling support. For anyone under 18, call Childline 1098. Emergency: 112.

How Nirvana Clinic can help. If you come to us, we will give you immediate care free of charge, as the law requires, and help you reach a government hospital for the medico-legal examination. Afterwards, Dr. Manuj Sondhi can look after your PEP course, follow-up tests and infection care, and Dr. Debolina Chowdhury (MD Psychiatry) offers confidential support for the emotional impact of trauma through our trauma care service.

How It Works

What to expect with PEP

1

Urgent assessment

A quick, confidential evaluation of the exposure and your risk, plus a baseline HIV test to confirm current status.

2

Start medication fast

If PEP is appropriate, a 28-day course of antiretroviral tablets is started without delay. (These are prescription medicines taken under medical supervision — not something to self-source.)

3

Complete the full course

All 28 days must be taken as directed; stopping early reduces protection. Side effects, if any, are managed along the way.

4

Follow-up testing

Repeat HIV testing after the course confirms the outcome. If you’re at ongoing risk, this is the moment to consider switching to PrEP.

Baseline Tests

What tests may be advised before or during PEP?

If the exposure is high-risk and within 72 hours, PEP is not delayed for test results — treatment starts and the work-up is done alongside. Baseline tests confirm your current status and keep treatment safe:

PurposeTests commonly advised
Current HIV statusHIV 4th-generation test; HIV RNA in selected high-risk or early-symptom cases
Medicine safetyKidney function, liver function, and a blood count where clinically needed
Other infectionsHepatitis B & C, syphilis, gonorrhoea & chlamydia as per exposure
Pregnancy carePregnancy test and emergency-contraception discussion where relevant
Testing must not cost time. If PEP is indicated, it is started urgently and the investigations are completed in parallel.
Follow-Up

Follow-up after starting PEP

Follow-up matters — to complete the 28-day course safely and to confirm HIV has not taken hold:

  • An early check for tolerance, adherence and side effects
  • HIV testing after completing the course, as advised
  • Further HIV testing around 4–6 weeks and 12 weeks after exposure, depending on the test used and your situation
  • STI and hepatitis follow-up where relevant
  • A PrEP discussion if future risk is likely
Risk Assessment

When PEP may not be needed

Not every contact needs PEP. A doctor weighs the type of exposure, the timing, the source’s status and your baseline HIV status. PEP is usually not needed for:

  • Touching, hugging, sharing food or utensils, toilet seats, or other casual contact
  • Intact-skin contact with no blood or genital-fluid exposure
  • Sex with a partner who is HIV-positive but consistently undetectable on treatment (U=U)
  • Exposure where the source is confirmed HIV-negative with no recent risk
If you’re unsure, still ask. A short consultation quickly decides whether PEP is needed — or safely rules it out, sparing you unnecessary medicine.
Important to Know

Honest limits and aftercare

  • PEP is emergency-only, not a regular method. For repeated or ongoing risk, PrEP is the right long-term prevention.
  • It is not 100%, but it substantially reduces the chance of HIV when started early and taken fully.
  • Consider other infections. The same exposure can carry STI or hepatitis risk, so STI testing is usually advised too.
  • Missed the window? If it has been more than 72 hours, PEP won’t help — but testing and a prevention plan still matter. Reach out.
Frequently Asked Questions

Common Questions

How long after exposure can I take PEP?
PEP must be started within 72 hours (3 days) of the possible exposure, and the sooner the better — ideally within hours. After 72 hours, PEP is generally not recommended as the expected benefit is very low, though you should still seek HIV testing, STI testing and prevention advice.
What if the exposure happens at night or the clinic is closed?
WhatsApp the clinic and book an online consultation with Dr. Manuj Sondhi from 8 AM the next morning; if PEP is needed, it can be started the same day. Do not wait for morning if more than 48 hours have already passed, if it was a sexual assault, or if the source is known to have HIV — go to the nearest hospital emergency department that night. Starting PEP sooner is always better.
Do I need PEP after a condom break?
PEP may be considered after a condom break if the partner is HIV-positive or of unknown status, or the exposure is otherwise high-risk. Timing is key — if it is within 72 hours, consult urgently. If the partner is confirmed undetectable on treatment, PEP may not be needed.
Can I take PEP after unprotected sex?
PEP may be advised after unprotected sex if there is a realistic possibility of HIV exposure. The doctor assesses the partner’s HIV status, the type of exposure, the timing and your baseline test before deciding.
How effective is PEP at preventing HIV?
PEP is highly effective when started early and the full 28-day course is taken correctly. It is not a guarantee, which is why prompt starting, full adherence, and follow-up testing all matter.
Is PEP confidential?
Yes. PEP care here is private, respectful and handled confidentially, in line with Indian law. Seeking PEP is a responsible, routine step and is treated as such.
What are the side effects of PEP?
Modern PEP is generally well tolerated. Some people get mild nausea, tiredness or headache, which usually settle and can be managed. Any concerns during the course can be reviewed with the doctor.
I keep having possible exposures — is PEP the answer each time?
Repeated PEP is a sign that ongoing prevention would serve you better. In that situation PrEP — medicine taken regularly to prevent HIV — is more effective and more practical. The doctor can help you switch.
What should I do after a sexual assault?
Get to a safe place and go to the nearest hospital emergency department as soon as you can; call 112 if you are in danger. Every hospital, government or private, must treat survivors of rape and child sexual abuse free of charge, and you do not need to file a police complaint first. Urgent care includes HIV PEP within 72 hours, emergency contraception if needed and prevention of other infections. Women Helpline 181 can connect you to further support.
Is PEP after a dog bite the same as HIV PEP?
No. The term PEP is also used for rabies prevention after an animal bite or scratch, which is a different treatment: thorough wound washing and a course of rabies vaccine, sometimes with rabies immunoglobulin. If an animal has bitten or scratched you, see a doctor the same day.
MS

Dr. Manuj Sondhi

MRCP (UK), MD, DNB · Consultant Physician & Diabetologist · 2-year Fellowship in Infectious Diseases & HIV, Tata Memorial Hospital · Visiting Consultant, Infectious Diseases, Fortis Greater Noida

With 15+ years in metabolic medicine, Dr. Manuj Sondhi cares for patients with diabetes, thyroid and weight-related conditions, and provides expert, confidential HIV, PrEP/PEP and infectious-disease care at Nirvana Clinic, Greater Noida (Delhi NCR). He believes clear information should help you understand your health — and that the right decision for your situation is best made together, in consultation.

Don’t wait — PEP is time-critical

If a possible exposure was within the last 72 hours, every hour counts. During clinic hours, call or WhatsApp now. At night, WhatsApp us and take the first online consultation from 8 AM — or go to a hospital emergency department tonight if you would rather not wait. If it has been longer than 72 hours, still reach out for testing and prevention advice.

Nirvana Clinic · Shop GF-93, Sun Twilight Mall, Opp. Delta 1 Metro Station, Greater Noida 201308

Medical disclaimer: This page is general health information, not a diagnosis or a substitute for a consultation. Whether PEP is right for you depends on an individual assessment by a doctor. PEP lowers the risk of HIV but does not remove it completely. Never start, stop or share antiretroviral medicines without medical supervision. In an emergency, call 112 or go to the nearest hospital emergency department.